Nocturnal Acid Breakthrough — Approach to Management
Previous Page In This ArticleAbstract and IntroductionWhat Is Nocturnal Acid Breakthrough?Clinical Importance of Nocturnal Acid BreakthroughTreatment of Nocturnal Acid BreakthroughConclusionFiguresReferences
Conclusion
In conclusion, nocturnal acid breakthrough frequently occurs in H pylori-negative patients taking daily or twice-daily PPIs. In asymptomatic patients on PPI therapy with uncomplicated GERD, the clinical importance of nocturnal acid breakthrough is likely low. However, in patients with complicated GERD, Barrett's esophagus, esophageal motility abnormalities, and symptomatic patients on PPI therapy, nocturnal acid breakthrough should be investigated and treated. In our experience, we have found bedtime H2RAs to be an effective treatment for nocturnal acid breakthrough.Previous PageSection 5 of 5
Medscape General Medicine. 2004;6(4):11. ©2004 Medscape
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